Familial Breast and Ovarian Cancer

This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in understanding the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in diagnosis, genetics, screening, prevention, and management. In addition, the volume discusses ethical and insurance issues, distinct cultural differences in breast cancer and use of recently devised cancer genetics clinics. The different referral criteria and patterns to these clinics are detailed.

Covers molecular biology and natural history, screening, and management
Includes advice on healthcare provision and setting up cancer genetics services
Includes the latest developments and their impact on the study and treatment of familial breast and ovarian cancer

Reviews & endorsements

"This text book is a timely publication and it gives a splendid overview of the genetics and management of familial breast and ovarian cancer...practical, up to date and well referenced...Colleagues throughout the profession from a wide range of disciplines will find much in this book to interest them and will help them guide and manage their patients through the difficult decision journey of familial cancer." Ulster Medical Journal

"...a very good state-of-the-art document of the current knowledge, covering most aspects of the genetic background and the clinical management of suspected familial breast and ovarian cancer...recommended for newcomers to the field of cancer genetics, and for those interested clinicians and policymakers who need a comprehensive base for maintaining and developing a clinical service." Hum Genet

"Over all, the text is very readable for a general scientific audience....This edited text covers all of the major areas of interest in considering familial and hereditary breast and ovarian cancers. Although the editors, most authors, and the focus on services are European, there are enough commonalities to make the book a worthwhile purchase for North American readers as well." American Journal of Human Genetics

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Product details

Published: December 2002
Format: Hardback
ISBN: 9780521803731
Length: 418 pages
Dimensions: 255 × 180 × 27 mm
Weight: 1.08kg
Contains: 52 tables
Availability: Available

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Contents

Part I. Molecular Biology and Natural History:
1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites
2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory
3. Cowden syndrome and related disorders Charis Eng
4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes
5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy
6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis
7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan
8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher
Part II. Screening:
9. Experience of setting up a cancer genetics service Jonathon Gray
10. Referral criteria for cancer genetics clinics Diana Eccles
11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson
12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson
13. Screening, detection and survival patterns of breast and other cancers in high risk families Pål Møller and Michael Steel
14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs
Part III. Management:
15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes
16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs
17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam
18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish
19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans
20. Ethical aspects Patrick Morrison and Michael Steel
21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston
22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites.

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About the authors

Contributors

Patrick Morrison, Shirley Hodgson, Neva Haites, Helen Gregory, Charis Eng, Pierre Chappuis, Will Foulkes, Hans Vasen, M. A. Nooy, Dominique Stoppa-Lyonnet, Will Foulkes, Pierre Chappuis, Sunil Lakhani, Adrienne M. Flanagan, Jenny Chang-Claude, Heiko Becher, Jonathon Gray, Diana Eccles, Pål Møller, Michael Steel, Barnaby Rufford, Usha Menon, Ian Jacobs, Pierre Chappuis, Will Foulkes, Dirk Brinkman, Ian Jacobs, Gareth Evans, Fiona Lalloo, Andrew Balidam, Steven Sutton, Alison Bish, Lucy Brooks, Richard Kennedy, Patrick Johnston

Editors

Patrick J. Morrison , Belfast City Hospital, Belfast
Patrick J. Morrison is a consultant clinical geneticist with a special interest in cancer genetics, in the Northern Ireland Regional Genetics Service. He qualified with an MB BCh BAO in 1986 and an MD in 1993 from Queens' University Belfast. He held molecular biology and neurogenetics research fellowships from the Royal College of Physicians in Ireland from 1991–4. Morrison is a member of the UK Government's Human Genetics Commission, World Federation of Neurology Research Group in Huntingdon Disease, a steering group member on the International Collaborative group on hereditary breast and ovarian cancer (ICG-HBOC) and a council member of the Irish Society of Human Genetics. He is involved in many other genetics and cancer societies, and has published over 100 peer-reviewed articles on all aspects of genetics, particularly late onset neurogenetics diseases, familial cancers and insurance issues.
Shirley V. Hodgson , Guy's Hospital, London
Neva E. Haites , University of Aberdeen
Neva E. Haites is a Professor in Medical Genetics at the University of Aberdeen and Head of Service in Medical Genetics and Honorary Consultant Clinical Genetics, Grampian University Hospitals NHS Trust. Her clinical interests include families with an inherited predisposition to cancer. She is currently Chair the Cancer Genetics Sub-Group of the Scottish Cancer Group at the Scottish Office and Chair of the British Society of Human Genetics. Haites' research Interests include service models for familial cancer, molecular aspects of Charcot Marie Tooth disease, polycystic ovarian syndrome, talipes equino varus, and diagnosis and identification of genes implicated in sporadic and familial cancer.

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