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Antiepileptic Drugs

All titles
Antiepileptic Drugs

Antiepileptic Drugs

Combination Therapy and Interactions
Jerzy Majkowski, Foundation of Epileptology, Warsaw
Blaise F. D. Bourgeois, Harvard University, Massachusetts
Philip N. Patsalos, Institute of Neurology, London
Richard H. Mattson, Yale University, Connecticut
July 2005
Available
Hardback
9780521822190
$230.00
USD
Hardback
USD
eBook
    Description

    This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed supported by clinical and experimental data. The book consists of five sections covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-morbid health conditions, and concludes with a look at the future directions for this field of research. The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic patients, including epileptologists, neurologists, neuro-pediatricians, psychiatrists and general practitioners.

    • Covers the benefits and pitfalls of combination therapy
    • Describes mechanisms of interactions as well as clinical significance
    • Contributions from an international team of authors and editors

    Reviews & endorsements

    'The book contains a wealth of information both for everyday practice and for more theoretical aspect. Interactions between AED … covered in great detail. … Why is this book so important? The authors explain it in their foreword. As a substantial proportion of patients with epilepsy will not become seizure free with one drug, combination therapy is necessary and therefore often used.' Official Journal of the European Paediatric Neurology Society

    See more reviews

    Product details

    July 2005
    Hardback
    9780521822190
    514 pages
    254 × 181 × 34 mm
    1.19kg
    16 b/w illus.
    Available

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    This title is available for institutional purchase via Cambridge Core

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    Contents

    Table of Contents

    • 1. Combination therapy of diseases: general concepts Emma Lam and Philip A. Routledge
    • 2. Combination therapy with antiepileptic drugs: potential advantages and problems Richard H. Mattson
    • 3. Pharmacogenetic aspects M. C. Walker, M. R. Johnson and Philip N. Patsalos
    • 4. Pharmacokinetic principles and mechanisms of drug interactions Philip N. Patsalos
    • 5. Predictability of metabolic antiepileptic drug interactions Edoardo Spina, Emilio Perucca and Rene Levy
    • 6. Influence of food and drugs on the bioavailability of antiepileptic drugs C. A. Fontes Ribeiro
    • 7. Interactions between antiepileptic drugs Bernhard Rambeck and Theodor W. May
    • 8. Interactions between antiepileptic and non-antiepileptic drugs Jerzy Majkowski and Philip N. Patsalos
    • 9. Pharmacodynamic principles and mechanisms of drug interactions Blaise F. D. Bourgeois
    • 10. Methods for assessing pharmacodynamic interactions Blaise F. D. Bourgeois
    • 11. Experimental studies of pharmacodynamic interactions Stanislaw J. Czuczwar
    • 12. Clinical studies of pharmacodynamic interactions John R. Pollard and Jacqueline French
    • 13. Clinical studies of pharmacodynamic interactions between antiepileptic agents and other drugs Gaetano Zaccara, Andrea Messori and Massimo Cincotta
    • 14. Antiepileptic drug interactions in children Olivier Dulac, Elizabeth Rey and Catherine Chiron
    • 15. Antiepileptic drug interactions in the elderly James C. Cloyd and Jeannine M. Conway
    • 16. Antiepileptic drug interactions in pregnancy Mark S. Yerby
    • 17. Antiepileptic drug interactions in handicapped and mentally retarded patients Matti Sillanpaa
    • 18. Antiepileptic drugs and sex steroids Richard H. Mattson
    • 19. Antiepileptic drug interactions in patients requiring psychiatric drug treatment Michael R. Trimble and Marco Mula
    • 20. Antiepileptic drugs in non-epileptic health conditions - possible interactions Jerzy Majkowski
    • 21. Drug monitoring in combination therapy W. Froscher
    • 22. Cognitive side-effects due to antiepileptic drug combinations and interactions Albert P. Aldenkamp, Mark de Krom, I. Kotsopoulos and Jan Vermeulen
    • 23. Selection of drug combinations in clinical practice - current and future perspectives Jerzy Majkowski
    • 24. Future research - an experimental perspective R. A. Voskuyl, D. M. Jonker and R. H. Lopes da Silva
    • 25. Future research - a clinical perspective C. A. Fontes Ribeiro.
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    About the authors
      Contributors

    • Emma Lam, Philip A. Routledge, Richard H. Mattson, M. C. Walker, M. R. Johnson, Philip N. Patsalos, Edoardo Spina, Emilio Perucca, Rene Levy, C. A. Fontes Ribeiro, Bernhard Rambeck, Theodor W. May, Jerzy Majkowski, Blaise F. D. Bourgeois, Stanislaw J. Czuczwar, John R. Pollard, Jacqueline French, Gaetano Zaccara, Andrea Messori, Massimo Cincotta, Olivier Dulac, Elizabeth Rey, Catherine Chiron, James C. Cloyd, Jeannine M. Conway, Mark S. Yerby, Matti Sillanpaa, Michael R. Trimble, Marco Mula, W. Froscher, Albert P. Aldenkamp, Mark de Krom, I. Kotsopoulos, Jan Vermeulen, R. A. Voskuyl, D. M. Jonker, R. H. Lopes da Silva

      • Editors
    • Jerzy Majkowski , Foundation of Epileptology, Warsaw
    • Blaise F. D. Bourgeois , Harvard University, Massachusetts
    • Philip N. Patsalos , Institute of Neurology, London
    • Richard H. Mattson , Yale University, Connecticut

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