The Hemopoietic Colony-stimulating Factors
The Hemopoietic Colony-stimulating Factors
Nicos Anthony Nicola, Walter and Eliza Hall Institute of Medical Research, Victoria
The colony-stimulating factors (CSFs) are the major regulators in the body of the production and activity of two types of white blood cells--granulocytes and macrophages. CSFs are used by clinicians to treat patients with damaged immune systems, for example, as a result of chemotherapy. This book provides a detailed and up-to-date account of the discovery of the CSFs, their structure, molecular biology and cellular receptors, the biology of the CSFs in vivo and in vitro, and their present and future clinical applications. Written by two of the pioneers in the discovery of CSFs, it is a clear and well illustrated survey of the history, current knowledge and future directions of this exciting field of investigation, and serves also as a guide to the more general areas of growth factor and cytokine research. It will prove an invaluable review for cell biologists interested in how growth factors act on the body, as well as for clinicians applying the fruits of modern biotechnology to improved patient care.
- Written by two of the pioneers in the discovery of CSFs; Metcalf is a world-renowned scientist
- Complete review of CSF's discovery, biology and clinical applications
- Beautiful illustrations, specially prepared for this book
Reviews & endorsements
"This book is and will be an excellent resource for scientists interested in the important area of hemopoietic stem cells and the proteins that regulate their behavior....The range of information from fundamental cell and molecular biology to the use of these agents in a clinical setting makes this book a valuable addition to any medical library." Alvin Telser, Doody's Health Sciences Book Review Journal
"...an excellent and well referenced (+700) work on the CSFs, and is a necessary addition to the library of the new and devoted researcher in the field." Gregory Denomme, Annales CRMCC
Product details
December 2006Paperback
9780521034814
356 pages
228 × 152 × 20 mm
0.537kg
72 b/w illus. 30 tables
Available
Table of Contents
- Preface
- 1. Historical introduction
- 2. General introduction to hemopoiesis
- 3. Key techniques in analyzing hemopoiesis
- 4. Biochemistry of the colony-stimulating factors
- 5. Biochemistry of the colony-stimulating factor receptors
- 6. Molecular genetics of the colony-stimulating factors and their receptors
- 7. Biological actions of the colony-stimulating factors in vitro
- 8. The biology of colony-stimulating factor production, degradation and clearance
- 9. Actions of the colony-stimulating factors in vivo
- 10. Role of the colony-stimulating factors in basal hemopoiesis
- 11. Actions of the colony-stimulating factors in resistance to infections
- 12. Role of the colony-stimulating factors in other disease states
- 13. The colony-stimulating factors and myeloid leukemia
- 14. Clinical uses of the colony-stimulating factors
- 15. Conclusions
- References
- Index.
