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Cancer Stem Cells

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Cancer Stem Cells

Cancer Stem Cells

August 2009
Available
Hardback
9780521896283
$127.00
USD
Hardback
USD
eBook
    Description

    A remarkable paradigm shift has occurred in recent years regarding the biological origins of cancer. The cancer stem cell hypothesis has challenged the foundational notions of cancer, and the therapeutic implications have been profound. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. Only this small sub-population of cells has the inherent ability to form tumors and metastasize. This book discusses the emerging field of cancer stem cell research, with contributions from leading experts on the basic biology, genetic pathways, and potentials for therapeutic targeting of cancer stem cells. It also covers clinical challenges for these new discoveries, namely, that cancer stem cells might be resistant to conventional chemotherapeutic and radiological treatments and may be at the biological core of relapse and therapeutic resistance. This book is an essential concise guide to the latest discoveries and therapies in cancer research.

    • Leading experts on biology of cancer stem cells provide the most up-to-date and groundbreaking discoveries
    • Therapeutic approaches and interventions are explored making this a useful tool for clinicians
    • Genetic pathways and molecular targets covered in detail

    Reviews & endorsements

    "A succinct analysis of the concept of cancer stem cells (CSCs) in the context of basic and clinical science. The book describes important areas of cancer stem cell research including such topics as isolation and purification of CSCs, signaling pathways involved during self renewal, and pluripotency of these cells, as well as molecular approaches that may be employed to potentially target these pathways....Well written and describes in a general fashion the concepts necessary for basic comprehension of the biology and clinical relevancy of CSCs research. Most of the color illustrations are clear and useful in summarizing the important aspects of CSC research discussed in the text."
    --Doody's Review Service

    See more reviews

    Product details

    August 2009
    Hardback
    9780521896283
    182 pages
    260 × 182 × 16 mm
    0.64kg
    12 b/w illus. 16 colour illus. 9 tables
    Available

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    This title is available for institutional purchase via Cambridge Core

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    Contents

    Table of Contents

    • Preface William L. Farrar
    • 1. Purification and characterization of cancer stem cells Elaine M. Hurt and William L. Farrar
    • 2. Prostate cancer stem cells Collene R. Jeter and Dean G. Tang
    • 3. Melanoma cancer stem cells Alexander Roesch and Meenhard Herlyn
    • 4. Mammospheres and breast carcinoma Massimiliano Bonafe
    • 5. Preventative and therapeutic strategies for cancer stem cells Stewart Sell and Gennadi Glinsky
    • 6. Targeting AML stem cells Monica L. Guzman, Gerrit J. Schuurhuis, and Craig T. Jordan
    • 7. Plasticity of multi-potent tumor cells and ES cells Lynne-Marie Postovit, Naira V. Margaryan, Elisabeth A. Seftor, Luigi Strizzi, Richard E. B. Seftor, and Mary J. C. Hendrix
    • 8. Hedgehog and GLI signaling in cancer Fritz Aberger
    • 9. Targeting notch signaling pathway in cancer stem cells Joon T. Park, Ie-Ming Shih, and Tian-Li Wang
    • 10. WNT-Beta catenin signaling in cancer Stephen Byers, Michael Pishvaian, Lopa Mishra, and Robert Glazer.
      • Show more

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    About the authors
      Contributors

    • William L. Farrar, Elaine M. Hurt, Collene R. Jeter, Dean G. Tang, Alexander Roesch, Meenhard Herlyn, Massimiliano Bonafe, Stewart Sell, Gennadi Glinsky, Monica L. Guzman, Gerrit J. Schuurhuis, Craig T. Jordan, Lynne-Marie Postovit, Naira V. Margaryan, Elisabeth A. Seftor, Luigi Strizzi, Richard E. B. Seftor, Mary J. C. Hendrix, Fritz Aberger, Joon T. Park, Ie-Ming Shih, Tian-Li Wang, Stephen Byers, Michael Pishvaian, Lopa Mishra, Robert Glazer

      • Editor
    • William L. Farrar

      William L. Farrar, PhD, is Head of the Cancer Stem Cell Section at the Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland.

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