Translational Medicine and Drug Discovery
Translational Medicine and Drug Discovery
This book, edited by two innovative leaders in the field, focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. Translational medicine seeks to translate biological and molecular knowledge of disease and how drugs work into innovative development strategies that reduce the cost and increase the speed of delivering new medicines for patients. This book outlines general strategies, biomarker development, imaging tools, translational human models and examples of their application to real drug development. The latest thinking is presented by researchers from many of the world's leading drug development companies, including Pfizer, Merck, Eli Lilly, Abbott and Novartis, as well as academic institutions and public-private partnerships that support translational research. This book is essential for anyone interested in translational medicine from a variety of backgrounds: university institutes, medical schools, pharmaceutical companies and drug development researchers and decision-makers.
- Discusses the new field of translational medicine and includes contributions from experts from the world's leading drug development companies and institutes, including Pfizer, Merck, Eli Lilly, Abbott and Novartis
- Contains current research information and real drug project and biomarker development examples
- Describes how the discipline of translational medicine has evolved to address the key problem in drug development today, namely unsustainable high-cost phase II attrition
Reviews & endorsements
"This timely book provides an insightful, comprehensive compilation of contemporary issues related to the discipline of translational medicine, with particular application to early drug development... the editors appear to have accomplished their attention of providing biomedical researchers a condensed yet detailed reference... This reasonably priced book is particularly recommended for scientists new to the discipline."
MF Paine, Clinical Pharmacology & Therapeutics
"This is an important book in a relatively new and growing field. Anyone engaged in advanced research designed to bring new drugs and biologics to market will find it valuable."
Edward Tabor, Drug Information Journal
Product details
October 2014Paperback
9781107435940
384 pages
254 × 178 × 20 mm
0.67kg
49 b/w illus. 16 tables
Available
Table of Contents
- Part I. Translational Medicine: History, Principles and Application in Drug Development:
- 1. Overview of translational medicine and drug development Bruce H. Littman
- 2. Concepts and case studies: diabetes Ann Taylor and Roberto Calle
- 3. Challenges in atherosclerosis John Millar
- 4. Obesity: new mechanisms and translational paradigms Gregory Gaich and David E. Moller
- 5. Bone disorders: case studies of translational research S. Aubrey Stoch
- 6. Case studies in neuroscience: unique challenges and examples Gerard J. Marek
- 7. Translational medicine in oncology Dominic G. Spinella
- Part II. Biomarkers and Public-Private Partnerships:
- 8. Biomarker validation and application in drug development Pfizer Global Research and Development
- 9. Application of imaging methods in translational medicine Johannes T. Tauscher and Adam Schwarz
- 10. European innovative medicines initiative Ole J. Bjerrum and Hans H. Linden
- 11. Critical path institute and the predictive safety consortium Elizabeth Gribble Walker
- 12. The biomarker consortium David B. Lee
- Part III. Future Directions:
- 13. Improving the quality and productivity of pharmacometric modeling and simulation activities - the foundation for model-based drug development Thaddeus H. Grasela, Jill Fiedler-Kelly and Robert Slusser
- 14. Embracing change: a pharmaceutical industry guide to the 21st century Mervyn Turner.
