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Neurotransmitter Release and its Modulation

All titles
Neurotransmitter Release and its Modulation

Neurotransmitter Release and its Modulation

Biochemical Mechanisms, Physiological Function and Clinical Relevance
David A. Powis, University of Newcastle, New South Wales
Stephen J. Bunn, University of Newcastle, New South Wales
Klaus Starke
September 1995
Available
Paperback
9780521446167
$113.00
USD
Paperback
    Description

    The group of chemicals known collectively as neurotransmitters form the basis of a complex communication system between nerve cells. It is a system that is constantly subtly refined and regulated via the modulating action of other neurotransmitters, circulating hormones, the products of local tissues and the action of various drugs (from both medicinal and socially abused sources). In this book, acknowledged authorities concisely describe the basic mechanisms involved in neurotransmitter release modulation in the different parts of the nervous system. This includes a quantitative evaluation of the significance of modulation, a summary of its biological ramifications and potential clinical relevance.

    • International team of contributors, acknowledged experts in this field
    • A comprehensive integrated approach covering both basic science and biological and clinical relevance
    • Clear descriptions and illustration provide easy accessibility for the non-specialist and student reader

    Reviews & endorsements

    "This is a well-conceived book...[it] provides important background information for the neuroscientist...goes full circle in combining both the basic principles of neurotransmitter function with the clinical relevance of neurotransmitter release in the nervous system." Mark S. Luer, Doody's Health Sciences Book Review Journal

    See more reviews

    Product details

    September 1995
    Paperback
    9780521446167
    378 pages
    246 × 189 × 20 mm
    0.84kg
    120 b/w illus. 11 tables
    Available

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    Contents

    Table of Contents

    • Part I. Neurotransmitter Release:
    • 1. Mechanisms of exocytosis and the central role of calcium
    • 2. Co-transmission
    • 3. Models and mechanisms of neurotransmission
    • Part II. Modulation of Neurotransmitter Release: Basic Principles and Key Players:
    • 4. Modulation of neurotransmitter release
    • 5. Modulation by autoreceptors
    • 6. Modulation by heteroreceptors
    • 7. Modulation by hormones and local tissue factors
    • 8. Modulation by corticosteroid hormones
    • Part III. Modulation of Neurotransmitter Release: The Cellular Mechanisms Involved:
    • 9. Second messenger pathways in the modulation of neurotransmitter release
    • 10. Regulation of calcium influx as a basis for modulation
    • 11. Calcium-independent modulation
    • Part IV. Modulation of Neurotransmitter Release: Physiological Function:
    • 12. In vivo evidence for presynaptic modulation
    • 13. Modulation of secretion from neurosecretory cells
    • Part V. Modulation of Neurotransmitter Release: Clinical Relevance:
    • 14. Possible role of presynaptic receptors in hypertension
    • 15. Monoamine neurones and antidepressant treatments
    • 16. Modulation of neurotransmitter release by some therapeutic and socially-used drugs
    • 17. Beneficial therapeutic interventions via manipulation of presynaptic modulatory mechanisms.
      • Show more

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    About the authors
      Contributors

    • K. Starke, R. D. Burgoyne, T. R. Cheek, P. Sneddon, M. R. Bennett, L. Stjärne, J. A. Brock, B. B. Fredholm, J. J. Reid, Z. Khalil, P. D. Marley, M. Joëls, E. R. de Kloet, H. Majewski, M. Barrington, D. Bleakman, R. J. Miller, A. R. Wakade, D. A. Przywara, B. H. C. Westerink, M. R. Boarder, K. R. Borkowski, P. Blier, C. de Montigny, S. Wonnacott, M. Göthert, L. A. Chahl, M. Willow, G. M. Nicholson, T. C. Westfall

      • Editors
    • David A. Powis , University of Newcastle, New South Wales
    • Stephen J. Bunn , University of Newcastle, New South Wales
    • Klaus Starke

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