Brain Drug Targeting
Brain Drug Targeting
In this innovative and challenging book, William Pardridge, a world leader in the study of the blood-brain barrier and its clinical implications, argues that brain drug development has been restricted by the failure of adequate brain drug targeting. This is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the central nervous system.
- Challenges existing drug development strategies
- Points the way to new drug treatments for brain diseases
- Author is world leader in studies of the blood-brain barrier
Reviews & endorsements
"Just as the author does an excellent job arguing for the need for more work in this area, he also goes in depth describing all the inherent pitfalls as well as possible solution necessary to develop large-molecule pharmaceuticals for brain disease." The Annals of Pharmacotherapy April 2002
"...a book that will become a standard on drug targeting to the brain...a must for everybody who works in the field of brain drug delivery in academia as well as in the pharmaceutical industry." Journal of Clinical Pathology
"This is an excellent book, to be expected from a major researcher in the field. The lucid text is illuminated by an eclectic mix of diagrams and plates that will have a broad appeal to a wide audience within the biomedical, pharmaceutical and imaging sciences." British Journal of Neurosurgery
Product details
June 2001Hardback
9780521800778
372 pages
254 × 182 × 24 mm
0.933kg
Available
Table of Contents
- Preface
- 1. Drug targeting, drug discovery, and brain drug development
- 2. Invasive drug delivery
- 3. Lipid-mediated transport and carrier-mediated transport of small molecules
- 4. Receptor-mediated transcytosis of peptides
- 5. Vector discovery: genetically-engineered trojan horses for drug targeting
- 6. Linker strategies: the engineering of multi-functional drug formulations
- 7. Protein neuropathies and peptide radiopharmaceuticals
- 8. Antisense neurotherapeutics and imaging gene expression in vivo
- 9. Gene therapy of the brain
- 10. Blood-brain barrier genomics
- Epilogue
- Bibliography.
