Homocysteine in Health and Disease
Homocysteine in Health and Disease
$120.00
USDHigh levels of homocysteine have been identified as a very important risk factor in cardiovascular disease. Homocysteine-related abnormalities are also thought to contribute to birth defects and dementia, and there are many common acquired diseases, drugs and genetic disorders which adversely affect the metabolism of homocysteine. In this 2001 book a multidisciplinary team of experts in the field give a clear analysis of the biochemistry, genetics, epidemiology, clinical settings, causes, impact and treatment of homocysteine disorders. This is an unusually comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine in health and disease.
- Covers the basic science and clinical issues across the broad medical spectrum of this increasingly important area
- Unusually comprehensive
- Written by an international team of experts
Reviews & endorsements
"This book is impressive in its scope and comes at a time when many have heard of homocysteine but few really understand the molecule...an invaluable handbook." Journal of the Royal Society of Medicine
"Provides an excellent up-to-date review." Brain
"Homocysteine in Health and Disease, is the most up-to-date resource available on the subject" Brooklyn, NY Park Slope Courier Nov 2001
"There is no better starting point for anyone wishing to learn more about homocysteine and B vitamin metabolism ... this book provides ample 'food for thought.'" International Journal of Geriatric Psychiatry
"Homocysteine in Health and Disease gives a clear up-to-date analysis of the biochemistry and metabolism of homocysteine and the genetics, epidemiology, clinical settings, causes, impact and treatment of homocysteine disorders." Brooklyn NY Daily Eagle & Daily Bulletin Nov 2001
"[The editors] have successfully bridged the interface between the relevant basic and applied sciences and produced a beautifully balanced overview of the role of homocysteine in health and disease. There is no publication like it in this specialty, where it is likely to become the standard reference..." Graeme J. Hankey, Department of Neurology, Royal Perth Hospital, Perth, Western Australia
"[A] rigorous and comprehensive overview of the field of homocysteine and hyperhomocysteinemic states...a fine textbook that should be of interest to clinicians and basic scientist who are interested in homocysteine...a clear, comprehensive, authoritative guide to this complex topic." The New England Journal of Medicine Feb 2002
"This is a fine textbook that should be of interest to clinicians and basic scientists who are interested in homocysteine and its potential role in a variety of disease states. The authors and editors have all made important contributions to this evolving field and, from the perspective of their own investigative experience, offer the reader a clear, comprehensive, authoritative guide to this complex topic." Joseph Loscalzo, New England Journal of Medicine, Jan 2002
"Homocysteine in Health and Disease is a comprehensive book with good citation of contemporary primary literature. It does a nice job of describing the physiological relevance of homocysteine, an important amino acid that site at a crucial branch point between the remethylation (folate and methionine cycles) and transsulfuration pathways, and covers the pathophysiological and clinical consequences of defects in its metabolism...this book makes a compelling case for why we must take notice of hyperhomocysteinemai as a risk factor for cardiovascular disease. Primarliy, this book will be useful for independent study, and will be acceptable to graduate and professional students, clinicians and research scientists." Trends
"This book provides an excellent up-to-date review of scientific and clinical grounding of homocysteine metabolism in health and disease, illustrated attractively with useful diagrams and figures. It is well-indexed, with an extensive bibliography. This book will be of interest and a good reference text for both basic scientists and clinicians." Brain
Product details
July 2011Paperback
9781107402423
536 pages
280 × 210 × 27 mm
1.19kg
Available
Table of Contents
- 1. Introduction: historical overview and recent perspectives David Wilken and Bridget Wilken
- Part I. Biochemistry and Physiology
- Section I. Chemistry:
- 2. Practical chemistry of homocysteine and other thiols Donald W. Jacobsen
- 3. Biosynthesis and reactions of homocysteine thiolactone Hieronim Jakubowski
- 4. Homocysteine and lipid oxidation Jay W. Heinecke
- 5. Homocysteine, nitric oxide and nitrosothiols Andrew J. Gow, Fred Cobb and Jonathan S. Stamler
- Section II. Biochemistry and metabolism:
- 6. Biosynthesis of S-adenosylmethionine Jose M. Mato, Matias A. Avila and Fernado J. Corrales
- 7. S-adenosylmethionine-dependent methyltransferase Steven G. Clarke and Kelly Banfield
- 8. S-adenosylhomosysteine hydrolase Sean T. Prigge and Peter K. Chiang
- 9. Regulation of homocysteine metabolism James D. Finkelstein
- 10. Microbial modeling of human disease: homocysteine metabolism Rowena G. Matthews and Martha L. Ludwig
- 11. Folate metabolism Robert J. Cook
- 12. Cobalamin-dependent remethylation Ruma V. Banerjee and Horatiu Olteanu
- 13. Betaine-dependent remethylation Tim Garrow
- 14. The transsulfuration pathway Warren D. Kruger
- Section III. Physiology:
- 15. Cellular transport and tissue distribution Brian Fowler
- 16. Homocysteine and the kidney John T. Brosnan
- 17. Homocysteine and the nervous system Anne M. Molloy and Donald G. Weir
- Section IV. Clinical Chemistry:
- 18. Methodologies of testing Karsten Rasmussen and Jan Möller
- 19. Methionine loading Nicholas Dudman and Jonathan Silberberg
- Part II. Clinical Dysfunction and Hyperhomocysteinemia
- Section V. Genetic Disorders:
- 20. Cystathionine-ß-synthase and its deficiency Jan P. Kraus and Viktor Kozich
- 21. Inborn errors of folate and cobalamin metabolism David S. Rosenblatt
- 22. Polymorphisms of folate and cobalamin metabolism Rima Rozen
- Section VI. Acquired Disorders:
- 23. Folate deficiency Ralph Carmel
- 24. Cobalamin deficiency Ralph Carmel
- 25. Vitamin B6 deficiency Jesse F. Gregory III
- 26. Homocysteine in renal disease Margret Arnadottir and Björn Hultberg
- 27. Diseases and drugs associated with hyperhomocysteinemia Henk J. Blom
- 28. Lifestyle factors associated with hyperhomocysteinemia Stein Emil Vollset, Helga Refsum, Ottar Nygard and Per Ueland
- Section VII. Clinical Consequences of Hyperhomocysteinemia:
- 29. Epidemiology: vascular and thrombotic associations Petra Verhoef and Meir Stampfer
- 30. Homocysteine and coronary artery disease Killian Robinson
- 31. Homocysteine and cerebrovascular disease J. David Spence and James F. Toole
- 32. Peripheral arterial disease Godfried Boers
- 33. Venous disease Armando D'Angelo and Chiara Beltrametti
- 34. Homocysteine and hemostasis Katherine A. Hajjar
- 35. Cellular mechanisms of homocysteine pathogenesis in atherosclerosis Donald W. Jacobsen
- 36. Homocysteine and cardiovascular physiology Steven R. Lentz
- 37. Homocysteine and human reproduction T. K. A. B. Eskes
- Section VIII. Intervention and Therapy:
- 38. Modification of hyperhomocysteinemia John M. Scott
- 39. Design of clinical trials to test the homocysteine hypothesis of vascular disease Robert Clarke
- 40. What is a desirable homocysteine level? Johan B. Ubbink
- Index.
