Systems Biology
Systems Biology
$92.99
USDGenome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education.
- The first textbook in the new field of systems biology
- An associated website provides slides, projects and problems
- Features an open layout, summary points, guides to literature and lots of illustrations
Reviews & endorsements
"Systems Biology is a very readable introduction to the subject... make[s] it clear that this is an exciting time for biology."
Nigel Goldenfeld, Physics Today
Product details
January 2006Hardback
9780521859035
336 pages
261 × 20 × 181 mm
0.8kg
Available
Table of Contents
- Preface
- 1. Introduction
- 2. Basic concepts in systems biology
- Part I. Reconstruction of Biochemical Networks:
- 3. Metabolic networks
- 4. Regulatory networks
- 5. Signalling networks
- Part II. Mathematical Representation of Reconstructed Networks:
- 6. Basic features of S
- 7. Topological properties
- 8. Fundamental subspaces
- 9. Null space of S
- 10. The left null space of S
- 11. The row and column spaces of S
- Part III. Capabilities of Reconstructed Networks:
- 12. Dual causality
- 13. Properties of solution spaces
- 14. Sampling properties of solution spaces
- 15. Finding functional states
- 16. Parametric sensitivity
- 17. Epilogue
- Appendix A: nomenclature and abbreviations
- Appendix B: E. coli core metabolic network
- Bibliography
- Index.
