Alloimmune Disorders of Pregnancy
Alloimmune Disorders of Pregnancy
Collectively known as the alloimmune cytopenias, hemolytic disease of the fetus and newborn, alloimmune thrombocytopenia and alloimmune neutropenia are all consequences of maternal immunisation to fetal blood cells. The effective prevention, diagnosis and management of these disorders has become a team effort involving haematologists, obstetricians, paediatricians, immunologists, laboratory technicians, midwives and research scientists. This book has been written by experts in their respective fields to bring together the issues of pathogenesis, epidemiology, prevention, diagnosis and clinical management. This comprehensive but accessible account is extensively cross-referenced to emphasise the links between pathogenesis and clinical sequelae, between epidemiology and the rationale for screening programmes, and between diagnosis and therapeutic intervention. This is an authoritative overview suitable for trainees in obstetrics, materno-fetal medicine, transfusion medicine and clinical immunology.
- First authoritative single-volume compilation on this important group of disorders
- Combines pathophysiology, epidemiology, diagnosis and laboratory investigation, and treatment and management
- Multi-disciplinary team of authors provide in-depth coverage
Product details
August 2005Paperback
9780521018043
308 pages
254 × 178 × 20 mm
0.812kg
24 b/w illus. 35 tables
Available
Table of Contents
- Preface Andrew G. Hadley and Peter Soothill
- 1. Pathophysiology of the alloimmune cytopenias Andrew G. Hadley and Craig Turner
- 2. Blood group antibodies in haemolytic disease of the fetus and newborn Geoff Daniels
- 3. Basis and practice of screening for haemolytic disease of the fetus and newborn Geoff Poole
- 4. Epidemiology and screening for alloimmune thrombocytopenia Lorna M. Williamson and Michael F. Murphy
- 5. Principles of antibody-mediated immune suppression and the prevention of maternal Rh(D) alloimmunisation Belinda Kumpel
- 6. The clinical application of anti-D prophylaxis Stan Urbaniak
- 7. Fetal genotyping Neil D. Avent
- 8. Laboratory assays to determine the severity of haemolytic disease of the fetus and newborn Andrew G Hadley
- 9. Assessing the severity of haemolytic disease of the fetus and newborn: clinical aspects Sherif Abdel-Fattah and Peter Soothill
- 10. Antenatal therapy for haemolytic disease of the fetus and newborn Kenneth J. Moise and Paul W. Whitecar
- 11. Neonatal therapy for haemolytic disease of the newborn Glynn Russell and Nic Goulden
- 12. The diagnosis of alloimmune thrombocytopenia Andrew Hadley
- 13. The diagnosis of alloimmune neutropenia Geoff Lucas
- 14. Fetal and neonatal treatment of alloimmune thrombocytopenia Michael Murphy, Rachel Rayment, David Allen and David Roberts
- Index.
