Brain Drug Targeting
Brain Drug Targeting
The thesis of this innovative and challenging book, first published in 2001, is that brain drug development has been restricted by the failure of adequate brain drug targeting, and that this is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author, a world leader in the study of the blood-brain barrier and its clinical implications, reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the central nervous system.
- Challenges existing drug development strategies
- Points the way to new drug treatments for brain diseases
- Author is world leader in studies of the blood-brain barrier
Reviews & endorsements
Review of the hardback: '… a book that will become a standard on drug targeting to the brain … a must for everybody who works in the field of brain drug delivery in academia as well as in the pharmaceutical industry.' W. Kamphorst, www.bmjbookshop.com
Review of the hardback: 'This book provides an extensive review of brain drug targeting of large molecules and will be a valuable reference to those interested in completing research in this field.' Tejal Patel, Doody's Health Sciences Book Review Journal
Review of the hardback: 'This is an excellent book to be expected from a major researcher in the field. The lucid text is illuminated by an eclectic mix of diagrams and plates that will have a broad appeal to a wide audience.' A. Davenport, British Journal of Neurosurgery
Product details
No date availablePaperback
9780521154468
376 pages
229 × 152 × 20 mm
0.5kg
Table of Contents
- Preface
- 1. Drug targeting, drug discovery, and brain drug development
- 2. Invasive drug delivery
- 3. Lipid-mediated transport and carrier-mediated transport of small molecules
- 4. Receptor-mediated transcytosis of peptides
- 5. Vector discovery: genetically-engineered trojan horses for drug targeting
- 6. Linker strategies: the engineering of multi-functional drug formulations
- 7. Protein neuropathies and peptide radiopharmaceuticals
- 8. Antisense neurotherapeutics and imaging gene expression in vivo
- 9. Gene therapy of the brain
- 10. Blood-brain barrier genomics
- Epilogue
- Bibliography.
