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Platelets in Hematologic and Cardiovascular Disorders

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Platelets in Hematologic and Cardiovascular Disorders

Platelets in Hematologic and Cardiovascular Disorders

A Clinical Handbook
Paolo Gresele, Università degli Studi di Perugia, Italy
Valentin Fuster, Mount Sinai School of Medicine, New York
Jose A. Lopez, Seattle University
Clive P. Page, King's College London
Jos Vermylen, Katholieke Universiteit Leuven, Belgium
January 2008
Available
Hardback
9780521881159
$228.00
USD
Hardback
USD
eBook
    Description

    A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

    • Covers all aspects of the involvement of platelets in disease, split into four main sections; platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy
    • Key information is summarized at the end of each chapter for quick reference
    • Illustrated with simple diagrams of key concepts, in colour throughout

    Reviews & endorsements

    "A comprehensive clinical handbook...Each aspect of the platelet is covered in detail by leading experts in the field...The first 19 chapters contain a good mix of basic science and clinical medicine...The last seven chapters of the book cover [the development of antiplatelet drugs] in great detail. Tables and graphs summarizing the main clinical trials of antiplatelet therapy complement the information and recommendations presented in these treatment-oriented chapters...I enjoyed reading this book and believe that it will be a useful guide for residents, graduate students, physicians, and scientists."
    --New England Journal of Medicine

    See more reviews

    Product details

    January 2008
    Hardback
    9780521881159
    526 pages
    252 × 198 × 30 mm
    1.408kg
    50 tables
    Available

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    This title is available for institutional purchase via Cambridge Core

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    Contents

    Table of Contents

    • Preface
    • 1. The structure and production of blood platelets Joseph E. Italiano, Jr
    • 2. Platelet immunology: structure, functions and polymorphisms of membrane glycoproteins Yasuo Ikeda, Yumiko Matsubara and Tetsuji Kamata
    • 3. Mechanisms of platelet activation Lawrence Brass and Timothy J. Stalker
    • 4. Platelet priming Paolo Gresele, Emanuela Dalcinelli and Stafania Momi
    • 5. Platelets and coagulation José A. López and Ian del Conde
    • 6. Vessel-wall-derived substances affecting platelets Azad Raiesdana and Joseph Loscalzo
    • 7. Platelet-Leukocyte-Endothelial cross talk Kevin J. Croce, Masashi Sakuma and Daniel I. Simon
    • 8. Laboratory investigation of platelets Eduard Shantsila, Timothy Watson and Gregory Y. H. Lip
    • 9. Clinical approach to the bleeding patient Jos Vermylen and Kathelijne Peerlinck
    • 10. Thrombocytopenia James Bussel and Andrea Primiani
    • 11. Reactive and clonal thrombocytosis Ayalew Tefferi
    • 12. Congenital disorders of platelet function Marco Cattaneo
    • 13. Acquired disorders of platelet function Michael H. Kroll and Amy A. Hassan
    • 14. Platelet transfusion therapy Sherrill J. Slichter and Ronald G. Strauss
    • 15. Clinical approach to the patient with thrombosis Brian G. Choi and Valentin Fuster
    • 16. Pathophysiology of arterial thrombosis Juan José Badimon, Borja Ibanez and Gemma Vilahur
    • 17. Platelets and atherosclerosis Stephan Lindemann and Meinrad Gawaz
    • 18. Platelets in other thrombotic conditions David L. Green, Peter W. Marks and Simon Karpatkin
    • 19. Platelets in respiratory disorders and inflammatory conditions Paolo Gresele, Stefania Momi, Simon C. Pitchford and Clive P. Page
    • 20. Platelet pharmacology Dermot Cox
    • 21. Antiplatelet therapy versus other antithrombotic strategies Nicolai Mejevoi, Catalin Boiangiu and Marc Cohen
    • 22. Laboratory monitoring of antiplatelet therapy Paul Harrison and David Keeling
    • 23. Antiplatelet therapy in cardiology Pierluigi Tricoc and Robert A. Harrington
    • 24. Antiplatelet therapy in cerebrovascular disease James Castle and Gregory W. Albers
    • 25. Antiplatelet treatment in peripheral arterial disease Raymond Verhaeghe and Peter Verhamme
    • 26. Antiplatelet treatment of venous thromboembolism Menno V. Huisman, Jaapjan D. Snoep, Jouke T. Tamsma and Marcel M. C. Hovens
    • Index.
      • Show more

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    Additional Information
    About the authors
      Contributors

    • Joseph E. Italiano, Jr, Yasuo Ikeda, Yumiko Matsubara, Tetsuji Kamata, Lawrence Brass, Timothy J. Stalker, Paolo Gresele, Emanuela Dalcinelli, Stafania Momi, José A. López, Ian del Conde, Azad Raiesdana, Joseph Loscalzo, Kevin J. Croce, Masashi Sakuma, Daniel I. Simon, Eduard Shantsila, Timothy Watson, Gregory Y. H. Lip, Jos Vermylen, Kathelijne Peerlinck, James B. Bussel, Ayalew Tefferi, Marco Cattaneo, Michael H. Kroll, Amy A. Hassan, Sherrill J. Slichter, Ronald G. Strauss, Brian G. Choi, Valentin Fuster, Juan José Badimon, Borja Ibanez, Gemma Vilahur, Stephan Lindemann, Meinrad Gawaz, David L. Green, Peter W. Marks, Simon Karpatkin, Simon C. Pitchford, Clive P. Page, Dermot Cox, Nicolai Mejevoi, Catalin Boiangiu, Marc Cohen, Paul Harrison, David Keeling, Pierluigi Tricoci, Robert A. Harrington, James Castle, Gregory W. Albers, Raymond Verhaeghe, Peter Verhamme, Menno V. Huisman, Jaapjan D. Snoep, Jouke T. Tamsma, Marcel M. C. Hovens

      • Editors
    • Paolo Gresele , University of Perugia, Italy

      Paolo Gresele is a Professor of Internal Medicine at the University of Perugia, Italy.

    • Valentin Fuster , Mount Sinai School of Medicine, New York

      Valentin Fuster is the Director of Mount Sinai Heart School of Medicine, New York.

    • Jose A. Lopez , Seattle University

      José A. López is the Executive Vice President for Research at the University of Seattle, Washington.

    • Clive P. Page , King's College London

      Clive P. Page is a Professor of Pharmacology at King's College London.

    • Jos Vermylen , University of Leuven, Belgium

      Jos Vermylen is an Emeritus Professor of Medicine at the University of Leuven, Belgium.

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