Molecular Biology of Bacterial Infection
Molecular Biology of Bacterial Infection
Charles W. Penn, University of Birmingham
C. J. Smyth, Trinity College, Dublin
Out of Print
Understanding virulence determinants of bacterial pathogens and their regulation, and the pathogenesis of bacterial infections, is essential to the development of safe and effective vaccines and therapeutic strategies. This book presents an authoritative account of the contributions being made by molecular genetics and improved analytical technology in uncovering the molecular basis of bacteria-host interactions in infections. The broad scope of the volume encompasses normal flora and colonization resistance, evolution of pathogenic mechanisms, genetic approaches to understanding bacterial pathogenesis and in vivo studies of mutants, antigenic variation, bacterial invasion, toxins, environmental control of gene expression, regulatory networks in gene control, and attenuation of virulence through auxotrophy. The book will provide a state of the art reference for researchers in all areas concerned with bacterial infection and will also be useful as an advanced text.
- Has the endorsement of a well-established and well-respected scientific society
- Another title in a productive and succesful series arising from popular and well-attended symposia
- Provides up-to-the-minute information about how the techniques of molecular biology have helped to investigate the phenomenon of bacterial infection in animals and in humans
Reviews & endorsements
' … excellent value for money and I would recommend it to all microbiologists with a passing interest in the pathogenesis of infection and bacterial virulence.' J. G. M. Hastings, Journal of Medical Microbiology
Product details
October 1992Hardback
9780521432986
343 pages
236 × 158 × 24 mm
0.694kg
Unavailable - out of print November 2002
Table of Contents
- 1. Normal flora and colonization resistance D. Van Der Waaij
- 2. Evolution of pathogenic mechanism M. Achtman
- 3. Genetic approaches to understanding pathogenesis of complex bacterial pathogens B. Finlay
- 4. Adhesion to and penetration of epithelial cells and intracellular behavior of invasive bacteria P. J. Sansonetti
- 5. Antigenic variation in bacterial pathogens T. F. Mayer
- 6. Capsules and LPS in invasive disease R. Moxon
- 7. Life within phagocytic cells S. H. E. Kaufmann
- 8. Bacterial latency, the carrier state and chronic infection C. Penn
- 9. Toxin-receptor interactions B. Wren
- 10. Super-antigen action of toxins R. O'Hehir
- 11. In vivo studies on mutants of pathogenic bacteria T. Foster
- 12. Toxins as delivery systems for antigens and drugs G. Dougan
- 13. Environmental control of expression of bacterial virulence determinants C. Dorman
- 14. Regulatory networks in control of expression of virulence factors in invasive bacteria G. Cornelis
- 15. Regulation of fimbrial biogenesis C. J. Smyth
- 16. Rational attenuation of bacterial pathogens S. Chatfield.
