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Principles of Pharmacogenetics and Pharmacogenomics

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Principles of Pharmacogenetics and Pharmacogenomics

Principles of Pharmacogenetics and Pharmacogenomics

Russ B. Altman, Stanford University, California
David Flockhart, Indiana University
David B. Goldstein, Duke University, North Carolina
March 2012
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9781139227568
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    Description

    The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.

    • This text provides state-of-the-art information on developments in pharmacogenetics and pharmacogenomics

    Product details

    March 2012
    Adobe eBook Reader
    9781139227568
    0 pages
    0kg
    27 b/w illus. 77 colour illus. 26 tables 37 exercises
    This ISBN is for an eBook version which is distributed on our behalf by a third party.

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    Contents

    Table of Contents

    • Introduction to population diversity and genetic testing: basic concepts Russ Altman, David Flockhart and David Goldstein
    • Part I. Critical Concepts:
    • 1. Introduction to population diversity and genetic testing James K. Burmester, Ingrid Glurich, Kimberly Pillsbury and Michael D. Caldwell
    • 2. Genotyping technologies Sharon Marsh and Cristi R. King
    • 3. Pharmacokinetics: absorption, distribution, metabolism, excretion Terry Blaschke
    • 4. Overview: adverse drug reactions Matthew Nelson
    • 5. PharmGKB, a centralized resource for pharmacogenomic knowledge and discovery Li Gong and Teri E. Klein
    • 6. DrugBank David S. Wishart
    • 7. Ethical considerations for pharmacogenomics: privacy and confidentiality Sandra Lee
    • 8. Informed consent in pharmacogenomic research and treatment Mark Rothstein
    • 9. Legal trends driving the clinical translation of pharmacogenomics Barbara Evans
    • Part II. Therapeutic Areas:
    • 10. Pharmacogenetics of oncologic drugs Uchenna Njaju and Eileen Dolan
    • 11. Pharmacogenetics of cardiovascular drugs Michael Stein and Danny Kurnik
    • 12. Pharmacogenomics of statin-induced muscle toxicity Ronald M. Krauss, Russell A. Wilke, Melissa Antonik and Elenita Kanin
    • 13. Pharmacogenomics of the drug-induced long QT syndrome Dan M. Roden, Prince J. Kannankeril, Stefan Kaab and Dawood Darbar
    • 14. Pharmacogenetics of diabetes drugs O. H. Klungel and Mark C. H. DeGroot
    • 15. Pharmacogenetics of respiratory drugs Kelan Tantisira and Scott Weiss
    • 16. Pharmacogenomics for acid-related gastrointestinal drugs Takahisa Furuta
    • 17. Pharmacogenetics of rheumatoid arthritis drugs Robert M. Plenge, Yvonne C. Lee, Souomya Raychaudhuri and Daniel H. Solomon
    • 18. Pharmacogenomics of obstetric drugs David Haas and Jamie Renbarger
    • 19. Pharmacogenomics of psychiatric drugs David Mrazek
    • 20. Pharmacogenomics of pain and anesthesia drugs Evan Kharasch and Konrad Meissner
    • 21. Pharmacogenetics of HIV and antiretroviral drugs Amalio Telenti
    • 22. Pharmacogenomics in pediatrics Jennifer A. Lowry and J. Steven Leeder
    • 23. Pharmacogenomics in fetal and neonatal medicine Yair Blumenfeld.
      • Show more
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    Additional Information
    About the authors
      Contributors

    • Russ Altman, David Flockhart, David Goldstein, James K. Burmester, Ingrid Glurich, Kimberly Pillsbury, Michael D. Caldwell, Sharon Marsh, Cristi R. King, Terry Blaschke, Matthew Nelson, Li Gong, Teri E. Klein, David S. Wishart, Sandra Lee, Mark Rothstein, Barbara Evans, Uchenna Njaju, Eileen Dolan, Michael Stein, Danny Kurnik, Ronald M. Krauss, Russell A. Wilke, Melissa Antonik, Elenita Kanin, Dan M. Roden, Prince J. Kannankeril, Stefan Kaab, Dawood Darbar, O. H. Klungel, Mark C. H. DeGroot, Kelan Tantisira, Scott Weiss, Takahisa Furuta, Robert M. Plenge, Yvonne C. Lee, Souomya Raychaudhuri, Daniel H. Solomon, David Haas, Jamie Renbarger, David Mrazeks, Evan Kharasch, Konrad Meissner, Amalio Telenti, Jennifer A. Lowry, J. Steven Leeder, Yair Blumenfeld

      • Editors
    • Russ B. Altman , Stanford University, California

      Russ Altman is Chairman of the Bioengineering Department and Professor of Bioengineering, Genetics, and Medicine at Stanford University. His primary research interests are in the application of computing technology to basic molecular biological problems of relevance to medicine.

    • David Flockhart , Indiana University

      David Flockhart is the Harry and Edith Gladstein Chair in Cancer Genomics and Professor of Medicine, Medical Genetics and Pharmacology at the Indiana University School of Medicine in Indianapolis. He is also the Director of the Division of Clinical Pharmacology. His research is focused on clinically relevant applications of pharmacogenetics and drug interactions.

    • David B. Goldstein , Duke University, North Carolina

      David Goldstein is the Richard and Pat Johnson Distinguished University Professor and Director of the Center for Human Genome Variation at Duke University. He is also Professor of Molecular Genetics and Microbiology at Duke. His principal interests include human genetic diversity, the genetics of disease and pharmacogenetics.

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