Dynamics of Engineered Artificial Membranes and Biosensors
Dynamics of Engineered Artificial Membranes and Biosensors
Vikram Krishnamurthy, Cornell University, New York
Bruce Cornell, University of Technology Sydney
£87.99
GBPLearn about the state of the art in building artificial membranes and synthetic biological devices, and in constructing mathematical models for their dynamics at multiple time and spatial scales with this comprehensive book. Drawing on recent advances in bioengineering and biochemistry, it describes how to engineer tethered bilayer lipid membranes, bioelectronic interfaces, high-resolution biosensors, and diagnostic devices for non-invasive cellular measurements and electroporation. Multi-physics models combining atomistic (molecular dynamics and coarse-grained molecular dynamics), mesoscopic (Poisson–Nernst–Planck), and macroscopic (reaction-rate theory) dynamics provide a complete structure-to-function description of these devices. Experiments and dynamic models explain how anti-microbial peptides penetrate membranes, how molecular machine biosensors built out of artificial membranes can detect femtomolar concentrations, and how electroporation can be controlled. Supported by atomistic simulation code online, this is essential reading for researchers, students and professionals in bioengineering, chemical engineering, biophysics, applied mathematics, and electrical engineering.
- The first book to provide a comprehensive treatment of artificial membranes: their design, construction, experimental studies, and mathematical models
- Includes an introduction to membrane biology and biochemistry
- Addresses building and modelling the bioelectronic interface, which is crucial for synthetic biological devices
Product details
May 2018Hardback
9781108423502
470 pages
253 × 178 × 26 mm
1.09kg
161 b/w illus. 16 tables
Available
Table of Contents
- Part I. Background:
- 1. Motivation and outline
- 2. Biochemistry for engineers: a short primer
- 3. Engineered artificial membranes
- Part II. Building Engineered Membranes, Devices and Experimental Results:
- 4. Formation of engineered tethered membranes
- 5. Ion-channel switch biosensor
- 6. Physiochemical membrane platforms
- 7. Experimental measurement methods for engineered membranes
- Part III. Dynamic Models for Artificial Membranes: Atoms-to-Device:
- 8. Reaction-rate constrained models for engineered membranes
- 9. Reaction-rate constrained models for the ICS biosensor
- 10. Diffusion constrained continuum models of engineered membranes
- 11. Electroporation models in engineered artificial membranes
- 12. Electroporation measurements in engineered membranes
- 13. Electrophysiological response of ion channels and cells
- 14. Coarse-grained molecular dynamics
- 15. All-atom molecular dynamics simulation models
- 16. Closing summary for part III: from atoms to device
- Appendices: Appendix A. Elementary primer on partial differential equations (PDE)
- Appendix B. Tutorial on coarse-grained molecular dynamics with peptides.
